ENVR 16 |
| Steven H. Lamm, Arnold Engel, Cecilia Penn, and Manning Feinleib. |
| Bladder cancer mortality among the villagers from the Blackfoot-Disease (BFD) endemic area of SW Taiwan have been attributed to the arsenic-concentrations in the village well water (e.g., Morales et al., 2000), although prior studies have shown additional risk factors including township, water source and BFD prevalence (Chen et al., 1985). Linear regression analysis shows that arsenic level accounts for 21% of the inter-village variance in bladder cancer mortality. In township-specific analysis, three of the six townships show a significant bladder cancer mortality rate that is independent of the arsenic levels and three reveal a significant dose-response relationship between arsenic level and bladder cancer mortality. Linear regression analysis for the later three townships shows that arsenic level accounts for 75% of the inter-village variance in bladder cancer mortality, but intriguingly best fitting a linear model beginning at 88 ppb. A number of toxicological mechanisms can explain this observation. |
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Occurrence, Chemistry, Toxicity and Remediation of Arsenic
8:00 AM-11:00 AM, Sunday, 26 March 2006 Georgia World Congress Center -- B218, Oral
Division of Environmental Chemistry |